TB4-FRAG
" RECOVER
FASTER
WITH LESS
ACHES & PAINS "
- SCOTT WILLIAMS
Scott Williams is a professional tennis coach at the highest level. Some of the professional players listed below have been coached by Scott.
• Tommy Haas ATP World Tour Singles #2
• Max Mirnyi ATP World Tour Doubles #1
• Mary Pierce WTA World Tour Singles & Doubles #3
• Anna Kournikova WTA World Tour Singles #8
Doubles Ranking #1
EVERYTHING YOU NEED, NOTHING YOU DON'T.
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No Artificial Colors, No Artificial Flavors, No Unnecessary Crap.
What is Thymosin Beta 4 Peptide?
Thymosin Beta 4 (TB4) is a naturally occurring multi-domain (multiple active sections) peptide that is produced in the thymus gland. The thymus starts shrinking around age 15 and continues to decline until approximately 80-90% of its activity has decreased by age 40, this is when the chronic diseases of aging start becoming more prevalent. The CDC states that approximately 80% of aged individuals are affected by at least one chronic disease due to declination of thymus related immune function [20,21]. TB4 provides a range of beneficial effects with the ability to stimulate and support tissue repair, healing, and regeneration for a range of tissues and organ systems [2,4]. TB4 is shown to support the down-regulation of inflammation and pain; [2,15] increase ATP (energy) production and protect and repair mitochondria; [1,2] increase antioxidant and glutathione production; [2,3,4,7,15] improve IGF-1 levels; [2] stimulate stem cell proliferation, activity, function and maturation. [4,5,13] Additionally, TB4 has significant antimicrobial functions; [1,2,4], helps maintain a normal and balanced immune system; [16,19] provides support and defense against environmental and internal toxins, including, pesticides, pollutants, antibiotics, alcohol, endotoxins mycotoxins and neurotoxins from infections and external sources; [1,15,18] modulates dysfunctional immunity; [1-5,8,9,14,16,19,20,21] supports the body’s repair functions in multiple systems of the body.;[ 2,10,15] and supports the body’s ability to stay healthy during aging [2,8,10,12,15,16,19].
Because full-length TB4 is 43 amino acids in length, it does not absorb orally, sub lingually or nasally.
• TB4 Frag is only four amino acids in length and is fully orally absorbable.
• Studies show that this four amino acid fragment maintains the immune-modulatory, healing as well as anti-inflammatory benefits of the complete TB4.
• TB4 fragment eliminates some of the few potential side-effects of full-lengthTB4, including eliminating the domain (AA 17-23) that stimulates mast cells. The active fragment is approximately ten times as potent as the full TB4 peptide on a per weight basis.
TB4 Fragment 1-4 is the workhorse of full-length TB4, possessing the immune-modulatory, angiogenic, healing, anti-inflammatory, cellular protective and repair actions of full-length TB4. TB4 Frag differentiates itself from full-length TB4 in the following ways:
• Orally active (absorbs intact).
• More potent antifibrotic.
• Ten times the potency of full-length TB4 by weight.
• Does not stimulate mast cell activation (segment 17-23).
• Crosses Blood Brain Barrier while full-length TB4 does not.
• Inhibits HTBFb induced Plasminogen Activator Inhibitor-1 (PAI-1), helping prevent the hypercoagulability seen with chronic illness [1,13].
THYMOSIN BETA 4 ACTIVE FRAGMENT
Injury Recovery
Boosts Immune System
Soft Tissue Repair
Nerve Regeneration
Improves Heart Health
Prevents Scar Tissue
Benefits of TB4-FRAG Include:
TB4 frag provides the body with many benefits that aim to protect it from injury and help it recover more quickly. While the body has the ability to heal on its own, when that healing is aided by the use of TB4 frag, it can return you to a sense of normalcy more quickly. It can also compensate for deficiencies in the body that may prevent it from completing these natural processes. Specifically, TB4 frag helps:
Boost the immune system – With its ability to help increase the white blood cell count, this supplement can help boost the body’s natural defenses against harmful germs and bacteria.
Improves heart health – The heart has the ability to repair itself, albeit at a very slow pace. Unfortunately, the muscles and tissue that are harmed as a result of a heart attack are not among the parts that are naturally repaired. However, TB4 frag may help in some of these areas and improve overall heart health.
Promotes good liver health – When the liver is damaged, repair can be difficult. TB4 frag has an innate ability to help with the regeneration of tissue, which can promote liver health.
Aids in healing wounds – When you are injured, your body takes time to heal the wound naturally. TB4 frag can help accelerate this process.
Improves eye health – The eye is a delicate part of the body that has natural defense mechanisms but is still subject to injury. TB4 frag can help protect the eye and help it heal when it does suffer injury.
Promotes nerve regeneration – With its ability to help in cell regeneration and healthy growth, TB4 frag helps the nervous system respond to injuries by supporting the regrowth of nerves.
Improves brain health – The protective and regenerative nature of TB4 frag helps several areas of the body, including the brain. As it helps with cellular development, it can help reduce blood clots in the body, which also helps to protect the brain against strokes or other traumatic brain injuries.
In addition to these benefits, it can also help to improve the lungs, help balance blood sugar levels and help to improve blood pressure. TB4 frag can also help facilitate the development of cells while also encouraging cell migration. Its usage can help improve the ability of the heart to receive and transmit oxygen throughout the cells of the body. It works to help the heart function as it was intended.
When the heart is functioning as it should, its ability to generate T cells through hormone production can help improve the body’s immune system. In addition, TB4 frag helps the body to produce B cells. This, in turn, helps the plasma cells create antibodies.
TB4-frag usage has long been a component of many recommended treatments by medical professionals as an aid for recovering from injury. It has been a favorite of professional athletes to help them stay at peak performance. In addition, TB4 frag can be used to help treat the following conditions:
• Arthritis – A benefit of the TB4 frag peptide is that it helps to combat inflammation. This can include inflammation of the joints, which is better known as arthritis.
• Blood Clots – With its benefit to overall heart health, TB4 frag can help to improve the cells in the body and treat blood clots that may have formed.
• Tissue Damage – Soft tissue injuries are quite common as a result of both accidents and surgeries. When damage occurs to muscles, ligaments, and tendons, TB4 frag can help facilitate the overall tissue generation and healing process, improving its speed and efficacy. It may also help reduce the chances of scarring.
• Autoimmune Disease – Because it helps to improve the body’s immune system, TB4 frag may assist with improving the fight against autoimmune diseases. This includes Lyme disease and even some traumatic brain injuries.
• Cardiovascular and Neurological Damage – With its ability to promote new blood cell creation, TB4 frag can help to improve cardiovascular and neurological health.
These benefits are just a few of the ways TB4 frag could help you improve your recovery, disease resistance and overall health and wellness. In addition to these, TB4 frag may also calm muscle fiber stress, improve muscle tone, assist with body flexibility, help cells exchange nutrients and other substances and more.
Synergistic effects of TB4 Fragment (Ac-SDKP) and BPC-157
The benefits of TB4 frag and BPC-157 generally arise from the fact that these two peptides affect the same cells in slightly different ways. TB4 frag boost cell migration and cell motility, this may sound trivial, but the ability of cells like fibroblasts to get to sites of injury is a rate limiting step in tissue repair. Many of these cells die before they reach their destination or simply don’t last long once they get there, so boosting their ability to move around is of massive benefit. Combining the ability of cells to get to the site of injury with an ability to function better and for longer once they are there is a triple synergy. This is where BPC-157 builds on the benefits of TB4 frag. BPC-157 improves fibroblast cell function by increasing growth hormone receptor density, thus improving both the longevity of these cells and their ability to grow/divide during the healing process. The result is that more cells get to the site of tissue injury and they are healthy when they get there. Healthy cells not only do more work, they produce more offspring that can then also do more work. This is why combining TB4 frag with BPC-157 is likely not just an additive process, but a multiplicative process. The benefits build on one another to dramatically increase tissue repair following injury.
Synergy in Neurological Recovery
TB4 frag has been shown in animal models to encourage the growth and proliferation of both central and peripheral nervous system tissues following injury. It is thought that TB4 activates the cells that support neurons, allowing them to provide more nutrients to the damaged cells as they recover [C]. These studies have shown that TB4 administration leads to substantial improvements in behavior, motor control and cognitive impairment [D].
Research also indicates that TB4 frag can help to reduce oxidative stress and improve the recovery of neural stem cells. BPC-157 may play a similar role in the brain as research has shown that it protects somatosensory neurons from injury by reducing inflammation in the nervous system [E]. BPC-157 also plays a protective role in the central nervous system, helping it to prepare for damage before it happens. It isn’t clear how it achieves this function specifically, but it does play an important role in signaling from the GI system. Researchers think that it may act as an early warning molecule to the brain, letting it know that noxious damage is on the way so that it can prepare. It is believed that BPC-157 helps the brain to maintain homeostasis even in the setting of traumatic injury.
TB4 frag has been tested in animal models of multiple sclerosis and found to help decrease levels of inflammatory molecules in the brain. This results in reversal of demyelination, the hallmark of multiple sclerosis and a marker of disease severity [F]. This benefit is probably mediated by enhanced neural supportive cell migration.
Together, BPC-157 and TB4 frag could substantially impact the health of the nervous system by reducing inflammation and oxidative stress, protecting cells that support neurons, and improving migration of cells that are responsible for tissue repair.
Muscle Recovery and Bone Strength with TB-4 Fragments (Ac-SDKP) and BPC-157
BPC-157 is an efficient promoter of tendon healing. Tendons are notoriously difficult to repair following injury and generally require surgical intervention to restore full function and range of motion [G]. Research shows that BPC-157 accelerates tendon repair by boosting fibroblast outgrowth and migration. Interestingly, BPC-157 also improves the quality of the repair. BPC-157 not only speeds recovery of injured tendons but it improves the outcome such that the tendon is stronger and more functional than had BPC-157 not been administered [H].
TB4 frag is effective in speeding musculoskeletal recovery both following injury and following exercise. Because it speeds the rate of migration of cells, it would directly impact tendon repair where fibroblast migration has been observed to be slow and incomplete under natural circumstances. The slow migration of immune cells and fibroblasts into tendons is at least in part because of poor blood supply. Both BPC-157 and TB4 frag are angiogenic and accelerate the growth of blood vessels. Together, these peptides can boost blood supply to injured tissue, particularly to tissue like tendons which have inadequate blood supply for healing. This not only speeds recovery by getting repair cells where they need to be, it improves the final outcome by increasing extracellular matrix deposition.
Another way in which BPC-157 and TB4 frag interact to help heal musculoskeletal injuries is boosting growth hormone. Research shows that BPC-157 increases the expression of growth hormone receptors on fibroblasts. Growth hormone is extremely important in musculoskeletal development and repair. BPC-157 circumvents some side effects by boosting receptors rather than the hormone itself [I]. This leads to targeted benefits in tissue repair without as many traditional side effects. So, fibroblasts essentially receive a boost of growth hormone by expressing more receptors, which can lead to their proliferation and increase their longevity. Combined with the motility effects of TB4 frag, BPC-157 can enhance the function of fibroblasts. In other words, not only are there more repair cells to get the work done, the cells that are involved in the repair are more effective. The benefits stack up on one another to potentially supercharge the healing process.
References
[1] Ildiko Bock-Marquette, Maar, K., Maar, S., Balint Lippai, Gabor Faskerti, Ferenc Gallyas, Olson, E. N., & Srivastava, D. (2023). Thymosin beta-4 denotes new directions towards developing prosperous anti-aging regenerative therapies. International Immunopharmacology, 116, 109741–109741. https://doi.org/10.1016/j.intimp.2023.109741
[2] Jakša Vukojević, Marija Milavić, Darko Perović, Spomenko Ilić, Andrea Zemba Čilić, Nataša Đuran, Sanja Štrbe, Zoran Zoričić, Igor Filipčić, Petrana Brečić, Sven Seiverth, & Predrag Sikirić. (2022). Pentadecapeptide BPC 157 and the central nervous system. Neural Regeneration Research, 17(3), 482–482. https://doi.org/10.4103/1673-5374.320969
[3] Lau, J. L., & Dunn, M. K. (2018). Therapeutic peptides: Historical perspectives, current development trends, and future directions. Bioorganic & Medicinal Chemistry, 26(10), 2700–2707. https://doi.org/10.1016/j.bmc.2017.06.052
[4] Maar, K., Hetenyi, R., Maar, S., Faskerti, G., Hanna, D., Lippai, B., Takatsy, A., & Bock-Marquette, I. (2021). Utilizing Developmentally Essential Secreted Peptides Such as Thymosin Beta-4 to Remind the Adult Organs of Their Embryonic State-New Directions in Anti-Aging Regenerative Therapies. Cells, 10(6), 1343. https://doi.org/10.3390/cells10061343
[5] Thymosin Beta-4 – an overview | ScienceDirect Topics. (2012). Sciencedirect.com. https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/thymosin-beta-4
[6] Goldstein, A. L., Hannappel, E., Sosne, G., & Kleinman, H. K. (2011). Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opinion on Biological Therapy, 12(1), 37–51. https://doi.org/10.1517/14712598.2012.634793
[7] Thymosin Beta 4. (n.d.). Leader in Anti-Aging & Hormone Replacement for Men and Women in USA. Retrieved March 28, 2024, from https://www.genemedics.com/thymosin-beta-4
[8] CROCKFORD, D. (2007). Development of Thymosin beta4 for Treatment of Patients with Ischemic Heart Disease. Annals of the New York Academy of Sciences, 1112(1), 385–395. https://doi.org/10.1196/annals.1415.051
[9] Kumar, S., & Gupta, S. (2011). Thymosin Beta 4 Prevents Oxidative Stress by Targeting Antioxidant and Anti-Apoptotic Genes in Cardiac Fibroblasts. PLoS ONE, 6(10), e26912. https://doi.org/10.1371/journal.pone.0026912
[10] Thymosin Beta 4 (TB4) Peptide: Benefits, Dosage, Side Effects. (2023, January 28). https://muscleandbrawn.com/peptides/thymosin-beta-4-overview/
[11] Professional Monograph Thymosin Beta 4 (Tb4). (n.d.). Retrieved March 28, 2024, from https://northamptonintegrativemedicine.com/wp-content/uploads/2019/05/Thymosin-beta-4-Monograph-1.pdf
[12] Bao, W., Ballard, V. L., Needle, S., Hoang, B., Lenhard, S. C., Tunstead, J. R., Jucker, B. M., Willette, R. N., & Pipes, G. T. (2013). Cardioprotection by systemic dosing of thymosin beta four following ischemic myocardial injury. Frontiers in Pharmacology, 4, 149. https://doi.org/10.3389/fphar.2013.00149
[13] Christoffer K.-J. Stark, Miikka Tarkia, Kentala, R., Malmberg, M., Tommi Vähäsilta, Savo, M., Ville-Veikko Hynninen, Helenius, M., Saku Ruohonen, Juho Jalkanen, Pekka Taimen, Tero-Pekka Alastalo, Antti Saraste, Juhani Knuuti, Timo Savunen, & Juha Koskenvuo. (2016). Systemic Dosing of Thymosin Beta 4 before and after Ischemia Does Not Attenuate Global Myocardial Ischemia-Reperfusion Injury in Pigs. Frontiers in Pharmacology, 7. https://doi.org/10.3389/fphar.2016.00115
[14] Christoffer K.-J. Stark, Miikka Tarkia, Kentala, R., Malmberg, M., Tommi Vähäsilta, Savo, M., Ville-Veikko Hynninen, Helenius, M., Saku Ruohonen, Juho Jalkanen, Pekka Taimen, Tero-Pekka Alastalo, Antti Saraste, Juhani Knuuti, Timo Savunen, & Juha Koskenvuo. (2016). Systemic Dosing of Thymosin Beta 4 before and after Ischemia Does Not Attenuate Global Myocardial Ischemia-Reperfusion Injury in Pigs. Frontiers in Pharmacology, 7. https://doi.org/10.3389/fphar.2016.00115
