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60 Capsules per bottle
Immediate Release
Suggested dosing: Consistency is key to feel full benefits.
The standard recommended dose is 1 capsule in the morning and 1 capsule in the evening.
Synergy in Neurological Recovery
TB4 frag has been shown in animal models to encourage the growth and proliferation of both central and peripheral nervous system tissues following injury. It is thought that TB4 activates the cells that support neurons, allowing them to provide more nutrients to the damaged cells as they recover[C]. These studies have shown that TB4 administration leads to substantial improvements in behavior, motor control and cognitive impairment[D].
Research also indicates that TB4 frag can help to reduce oxidative stress and improve the recovery of neural stem cells. BPC-157 may play a similar role in the brain as research has shown that it protects somatosensory neurons from injury by reducing inflammation in the nervous system[E]. BPC-157 also plays a protective role in the central nervous system, helping it to prepare for damage before it happens. It isn’t clear how it achieves this function specifically, but it does play an important role in signaling from the GI system. Researchers think that it may act as an early warning molecule to the brain, letting it know that noxious damage is on the way so that it can prepare. It is believed that BPC-157 helps the brain to maintain homeostasis even in the setting of traumatic injury.
TB4 frag has been tested in animal models of multiple sclerosis and found to help decrease levels of inflammatory molecules in the brain. This results in reversal of demyelination, the hallmark of multiple sclerosis and a marker of disease severity[F]. This benefit is probably mediated by enhanced neural supportive cell migration.
Together, BPC-157 and TB4 frag could substantially impact the health of the nervous system by reducing inflammation and oxidative stress, protecting cells that support neurons, and improving migration of cells that are responsible for tissue repair.
Muscle Recovery and Bone Strength with BPC 157 and TB-4 Frag
BPC-157 is an efficient promoter of tendon healing. Tendons are notoriously difficult to repair following injury and generally require surgical intervention to restore full function and range of motion[G]. Research shows that BPC-157 accelerates tendon repair by boosting fibroblast outgrowth and migration. Interestingly, BPC-157 also improves the quality of the repair. BPC-157 not only speeds recovery of injured tendons but it improves the outcome such that the tendon is stronger and more functional than had BPC-157 not been administered[H].
TB4 frag is effective in speeding musculoskeletal recovery both following injury and following exercise. Because it speeds the rate of migration of cells, it would directly impact tendon repair where fibroblast migration has been observed to be slow and incomplete under natural circumstances. The slow migration of immune cells and fibroblasts into tendons is at least in part because of poor blood supply. Both BPC-157 and TB4 frag are angiogenic and accelerate the growth of blood vessels. Together, these peptides can boost blood supply to injured tissue, particularly to tissue like tendons which have inadequate blood supply for healing. This not only speeds recovery by getting repair cells where they need to be, it improves the final outcome by increasing extracellular matrix deposition.
Another way in which BPC-157 and TB4 frag interact to help heal musculoskeletal injuries is boosting growth hormone. Research shows that BPC-157 increases the expression of growth hormone receptors on fibroblasts. Growth hormone is extremely important in musculoskeletal development and repair. BPC-157 circumvents some side effects by boosting receptors rather than the hormone itself[I]. This leads to targeted benefits in tissue repair without as many traditional side effects. So, fibroblasts essentially receive a boost of growth hormone by expressing more receptors, which can lead to their proliferation and increase their longevity. Combined with the motility effects of TB4 frag, BPC-157 can enhance the function of fibroblasts. In other words, not only are there more repair cells to get the work done, the cells that are involved in the repair are more effective. The benefits stack up on one another to potentially supercharge the healing process.
BPC-157+TB4-Frag
SYNERGYSTIC EFFECTS OF BPC-157 & TB4 FRAG
The benefits of TB4 frag and BPC-157 generally arise from the fact that these two peptides affect the same cells in slightly different ways. TB4 frag boost cell migration and cell motility, this may sound trivial, but the ability of cells like fibroblasts to get to sites of injury is a rate limiting step in tissue repair. Many of these cells die before they reach their destination or simply don’t last long once they get there, so boosting their ability to move around is of massive benefit. Combining the ability of cells to get to the site of injury with an ability to function better and for longer once they are there is a triple synergy. This is where BPC-157 builds on the benefits of TB4 frag. BPC-157 improves fibroblast cell function by increasing growth hormone receptor density, thus improving both the longevity of these cells and their ability to grow/divide during the healing process. The result is that more cells get to the site of tissue injury and they are healthy when they get there. Healthy cells not only do more work, they produce more offspring that can then also do more work. This is why combining TB4 frag with BPC-157 is likely not just an additive process, but a multiplicative process. The benefits build on one another to dramatically increase tissue repair following injury.